As the disease progresses, the jaws become rigid to the point that the person is unable to open the mouth. O ral submucous fibrosis is a chronic, insidious disease affecting the oral cavity and sometimes pharynx. A total of 96 patients with oral submucous fibrosis have received four regimens of treatmentlocal dexamethasone, local hyaluronidase, local combination of dexamethasone and hyaluronidase, and local placental extract. Oral submucous fibrosis osmf is a chronic, progressive, debilitating. A novel clinical protocol for therapeutic intervention in oral. Successful use of inferiorly based nasolabial flaps in the management of oral submucous fibrosis is.
Drug treatment for oral submucous fibrosis evidencebased. The suggested aetiological factor is the practice of certain customshabits of the inhabitants of south east asia. Journal of indian academy of oral medicine and radiology, januarymarch 2012. Oral submucous fibrosistreatment with hyalase the journal.
Oral submucous fibrosis is usually diagnosed when the disease is at an advanced stage and lesions are widespread. Definition it is an insidious chronic disease affecting any part of the oral cavity and sometimes the pharynx. If the disease is detected at a very early stage, cessation of the habit is sufficient. Oral submucous fibrosis osmf is a persistent, progressive, precancerous condition of the oral mucosa, which is related with betel quid chewing habit. Oral submucous fibrosis osmf, a precancerous condition of the oral cavity, has been studied by a number of workers in the field. Dental college, hospital and research institute, india introduction oral submucous fibrosis was first described by schwartz in 1952 among five indian females living in kenya and he coined.
Patients are advised to do mouthopening exercises, for example, by placing ice. Use of nasolabial flap in the management of oral submucous. The available epidemiological data showed a clearcut geographical and ethnic predisposition, which suggested that certain customshabits prevalent among the population groups in southeast asia might be possible etiological factors. Pdf an approach to management of oral submucous fibrosis. Clinicopathological study on submucosal injection of collagenase in the treatment of submucous fibrosis in the oral cavity. Symptoms include submucous fibrosis, ulceration, xerostomia, a burning sensation, and restricted mouth opening. Treatment etiopathogenesis and management of oral submucous fibrosis seema basoya department of oral medicine and radiology, s. Oral submucous fibrosis affects the oral tissue of the buccal mucosa, lips, soft palate, and occasionally the pharynx.
All of these greatly interfere with patient quality of life. Oral submucous fibrosis treatment peoplebeatingcancer. Oral submucous fibrosis osmf is a chronic, progressive disease that alters the fibroelasticity of the oral submucosa, prevalent in india and southeast asia but rare elsewhere, and characterized by burning and pain in the oral cavity, loss of gustatory sensation, the presence of blanched fibrous bands and stiffening of the oral mucosa and oro. Several classifications based on clinical and histological.
Medical and surgical treatment options for oral submucous. Clinical experience with the use of peripheral vasodilator in oral disorders. Oral submucous fibrosis osf is a high risk precancerous condition characterized by changes in the connective. Table 1 worldwide prevalence studies on oral submucous fibrosis. Unfortunately, there are no effective treatments for osf. Oral submucous fibrosis can be seen at any age except for young children. Oral submucous fibrosisa case report medcrave online.
Oral submucous fibrosis and the role of curcumin in its. These are injected into the fibrotic bands weekly for 68 weeks with regular monitoring of mouth opening. Various local grafts have been used to cover the buccal mucosal defects after the fibrotic bands are released in oral submucous fibrosis. Oral submucous fibrosis is a precancerous condition affecting the oral cavity, oropharynx and rarely esophagus, tongue and commonly seen in those consuming betel nut. Gupta s, reddy mvr, harinath bc, role of oxidative stress and antioxidants in aetiopathogenesis and management of oral submucous fibrosis, ind j clinbiochem, 19, 2004, 8. A number of studies have proven the use of antioxidants in the management of osmf.
Oral submucous fibrosis osmf is a highrisk premalignant condition largely seen in the indian subcontinent. Oral submucous fibrosis osmf is a chronic condition characterised by progressive stiffening of the oral mucosa with the resultant inability to open the mouth. The surgical management of this condition involves excision of the fibrotic bands and interpositional grafts to retain the increased oral opening. The study concludes that aloe vera can be an alternative, safe, and effective treatment regime in the management of oral submucous fibrosis. The disease is rare in north america, and most cases seen in. Oral submucous fibrosis osmf is a potentially malignant disease that results in progressive juxtaepithelial fibrosis of the oral soft tissues. Laser treatment video for oral submucous fibrosis part.
Oral submucous fibrosis and the role of curcumin in its treatment. Oral submucous fibrosis was first described by schwartz in 1952 among five indian females living in kenya and he coined the term atrophia idiopathica mucosae oris. Oraoral submucous fibrosis osmf is a chronic, insidious, disabling disease of oral mucosa, oropharynx, and rarely, the larynx affecting millions of people worldwide with a prevalence rate of 0. Pdf aloe vera in the management of oral submucous fibrosis. Coverage of the mucosal defect using flaps, grafts and collagen membranes. Oral submucous fibrosis osmf is a chronic, insidious, disabling disease involving oral mucosa the oropharynx, and rarely the larynx.
Yeh application of the buccal fat pad to the surgical treatment of oral submucous fibrosis int j oral maxillofac surg, 25 1996, pp. Although occasionally preceded andor associated with vesicle formation, is. Compared to traditional betel quid, gutkha chewing tends to begin at a younger age and has a shorter time to the development of disease, so cases of oral submucous fibrosis have been seen as young as 11 years of age. Comparison of mouth opening with different nonsurgical.
A common complaint is a progressive stiffness of the cheeks, which inhibits the ability to open the mouth. Jan 30, 2017 oraoral submucous fibrosis osmf is a chronic, insidious, disabling disease of oral mucosa, oropharynx, and rarely, the larynx affecting millions of people worldwide with a prevalence rate of 0. Oral submucous fibrosis osmf is a disease of unknown etiology. Pdf classification system for oral submucous fibrosis.
Each group consisted of ten patients with an age ranging from 30 75years. Laser treatment video for oral submucous fibrosis part 1. It is characterized by inflammation, increased deposition of submucosal collagen and formation of fibrotic bands in the oral and paraoral tissues, which increasingly limit. A thorough case history along with a detailed clinical. A new intraoral appliance for trismus in oral submucous fibrosis.
The symptoms and signs depend on the progression of the lesions and number of affected sites. Betel nut and pan are freely available in the united kingdom, and in a city such as leicester, one might expect to find 3000 cases of oral submucosal fibrosis. Treatment options for oral submucous fibrosis iosr journal. Advanced treatment of oral submucous fibrosis by dr. Jul 01, 20 oral submucous fibrosis osmf is a chronic, progressive disease that alters the fibroelasticity of the oral submucosa, prevalent in india and southeast asia but rare elsewhere, and characterized by burning and pain in the oral cavity, loss of gustatory sensation, the presence of blanched fibrous bands and stiffening of the oral mucosa and oro. The awareness of such a condition among oral physicians can help in timely diagnosis and. Oral submucous fibrosis osmf is an insidious precancerous disease mostly seen in the southeast asia. Oral submucous fibrosis causes, symptoms, treatment and. Application of the buccal fat pad to the surgical treatment of oral sub mucous fibrosis. Management of oral submucous fibrosis by different. The treatment of patients with oral submucous fibrosis depends on the degree of clinical involvement.
Worldwide, estimates of oral submucous fibrosis indicate that 2. Oral submucous fibrosis is a chronic disorder characterized by progressive fibrosis of the lining mucosa of the upper digestive tract involving the oral cavity, oropharynx, and frequently the upper third of the esophagus, resulting in intolerance to spicy foods, a. Effectiveness of pentoxifylline in the treatment of oral. Several glucocorticoids are used for the treatment of osmf, short acting. The tissue is symmetrically affected and becomes progressively firm and pale. Therefore, the aim of the present study was to compare the efficacy of two antioxidants, lycopene and aloe vera in the management of osmf. Oral submucous fibrosis osf is a premalignant condition mainly associated with the practice of chewing betel quid containing areca nut, a habit common among south asian people. Various procedures and graft material have been utilised with differing success rates. Pdf role of diode laser in oral submucous fibrosis ip. Oral submucous fibrosis osf is characterized by abnormal collagen deposition.
Oral submucous fibrosis osmf is a potentially malignant disorder largely seen in the southasian countries where areca nut is found to be the main predisposing factor. Oral submucous fibrosis an overview sciencedirect topics. Oral submucous fibrosis, a clinically benign but potentially. The available epidemiological data showed a clearcut geographical and ethnic predisposition, which suggested that certain. Pubmed, embase, web of science, and the cochrane library were searched. Existing treatments give only temporary symptomatic relief. Management of oral submucous fibrosis by different surgical. Oral sub mucous fibrosis is a crippling disease of mouth with high malignant potential that has high prevalence rate in india and south east asia. Dec 25, 2014 oral submucous fibrosis osmf is a potentially malignant disorder of the oral cavity. Pdf on jan 1, 2014, ramesh fry and others published an approach to management of oral submucous fibrosis.
Patients with oral submucous fibrosis osf suffer from the limitation of the oral opening. Osf generally progresses to oral cancer 316 y after the initial osf diagnosis 23,24. A retrospective study, int oral health, 7, 2015, 8285. Most patients with oral submucous fibrosis present with moderatetosevere disease. In patients with oral submucous fibrosis, the risk of developing oral carcinoma is 7.
Oral submucous fibrosis osmf is an insidious chronic progressive disease of the oral cavity which is considered as a precancerous condition. Prevention is most important, as no healing can be achieved with available treatments. Jun 26, 2010 the drugs used to treat oral submucous fibrosis osf were categorised into steroids, enzymes, cardiovascular drugs, antioxidants, vitamins and microelements. Oral submucous fibrosis osf is a premalignant condition caused by betel chewing. It results in difficulty to open the mouth and can be disabling to the patient. Index definition history keywords pathogenesis clinical features laboratory findings classification treatment 3.
Efficacy of salvianolic acid b combined with triamcinolone acetonide in the treatment of oral submucous fibrosis. Apr 18, 20 laser treatment video for oral submucous fibrosis part 1. Etiopathogenesis and management of oral submucous fibrosis. Classification system for oral submucous fibrosis chandramani bhagvan more, swati gupta, jigar joshi, saurabh n varma abstract oral submucous fibrosis osmf is a potentially malignant disorder pmd and crippling condition of oral mucosa. It is very common in southeast asia but has started to spread to europe and north america. Oral dysplasias and squamous cell carcinomas are complications of oral submucous fibrosis. We have mentioned all advanced treatments according to international standards and protocols needed for oral submucous fibrosis. The treatment aims at good release of fibrosis and to provide long term results in terms of mouth opening. The use of buccal fat pad in the treatment of oral. Oral submucous fibrosis is widely prevalent in all age groups and across all socioeconomic strata in india.
As the disease progresses, the oral mucosa becomes stiff due to the formation of fibrotic bands in the cheek, ultimately leading to. Oral submucous fibrosis osf is a precancerous condition of the oral mucosa. This paper aims to study on clinical profile of patients with osmf material. Although occasionally preceded andor associated with vesicle formation, is always associated with. Excision of fibrotic bands with scalpel or using lasers. It is well recognised as potentially malignant disorder which is associated mainly with the use of arecanut in various forms.
Oral submucous fibrosis osf is an extremely discomforting oral condition that is marked by the development of painful lesions inside the mouth that refuse to go away on their own. Comparative study of the efficacy of lycopene and aloe. Oral submucous fibrosisa new treatment regimen joms. Contents introduction definition epidemiology nomenclature classification etiopathogenesis clinical features histopathology differential diagnosis special investigations malignant potential treatment and management.
Stage iii osmf is seen in a young girl aged 14 years that depicts the increasing prevalence. At this stage surgical treatment is usually not possible, but systemic and intralesional injections of corticosteroids have been used with some success. Flowchart explaining the decrease in collagen degradation which increases the risk of osmf. The aim of this study was to develop a simple and rapid method to improve the opening of the oral cavity and determine its effect on the incidence of developing oral carcinoma. Oral submucous fibrosis osmf is a potentially malignant disorder of the oral cavity. R crri,saveetha dental college and hospitals, chennai abstract. It is a precancerous disorder and transforms into a malignant tumor in 1. Oral submucous fibrosis is a chronic disorder characterized by progressive fibrosis of the lining mucosa of the upper digestive tract involving the oral cavity, oropharynx, and frequently the upper third of the esophagus, resulting in intolerance to spicy foods, a burning sensation in the mouth, xerostomia, and limitation of mouthopening. Oral submucous fibrosis is a chronic, complex, premalignant 1% transformation risk condition of the oral cavity, characterized by juxtaepithelial inflammatory reaction and progressive fibrosis of the submucosal tissues the lamina propria and deeper connective tissues. Aetiology and management, arecanut, oral submucous fibrosis. Oral submucous fibrosis a disease with malignant potential report.
The present article discusses various management modalities available for oral sub mucous fibrosis. Intraoral appliance therapy can be employed as an alternative or adjuvant treatment for radiotherapyinduced fibrosis and autoimmune disorders such as scleroderma, psychogenic trismus, and oral submucous fibrosis, decreasing the adverse effects associated with other pharmacological interventions. Nov 24, 2012 oral submucous fibrosis osf is an extremely discomforting oral condition that is marked by the development of painful lesions inside the mouth that refuse to go away on their own. Oral submucous fibrosis is a disease due to a chronic, insidious change in fibroelasticity, characterized by burning sensation in the oral cavity, blanching, and stiffening of the oral mucosa and oropharynx leading to trismus and inability to open the mouth. Jun 18, 2018 the treatment of patients with oral submucous fibrosis depends on the degree of clinical involvement. Joshi subsequently coined the termed oral submucous fibrosis osf for the condition in 1953. In 1952, schwartz coined the term atrophica idiopathica mucosa oris to describe an oral fibrosing disease he discovered in 5 indian women from kenya.
Efficacy of aloe vera gel as an adjuvant treatment of oral submucous fibrosis. Oral submucous fibrosis 31 in europe or north america. Management of oral submucous fibrosis by two different drug. Treatment of oral submucous fibrosis by collagenase. Oral submucous fibrosis osf is the chronic debilitating and crippling condition of oral mucosa. Know all about the disease, including its possible causes, symptoms, diagnosis and treatment options. Total of 30 patients with clinically diagnosed osmf patients. Joshi 2 subsequently termed the condition oral submucous fibrosis osf in 1953. Efficacy of hyaluronidase combined with corticosteroids in. Sharma oral submucous fibrosis a new treatment regimen j oral maxillofac surg, 46 1988, pp.